Re-Imagining Nature in Dense, High Rise Urban Environment: the Present and Future of Green Building Infrastructure in Singapore

From the futuristic Jewel at Changi Airport, the healing gardens at Khoo Teck Puat Hospital in Yishun to School of the Arts at Orchard Road, greenery has sprouted in buildings vertically and horizontally in Singapore, painting a growing green canopy for the dense, high rise city. This paper combines both analyses from first-hand site visits and case studies from external scholar studies to examine the performance of existing Green Building Infrastructures (BGIs) within Singapore’s unique urban context. The study reveals that the success of BGIs is highly dependent on the programming (i.e. thermal comfort design, accessibility, amenity facilities etc.), as well as the function and users of the existing building. Designs and planning that take those factors into consideration while being in line with the city’s general development goals, such as storm water management and pervasive greenery, are likely to bring out the most benefits in BGIs. To demonstrate, this paper also proposed several policy and planning recommendations that included several sets of rudimentary yet relevant parameters. Future research is encouraged to explore more complex combinations of considerations, their incorporation in design and policy making process, as well as a scientific and systematic method to evaluate BGI performance that includes both objective environmental impacts and subjective user experience that might be achieved through smart city developments

Distinct cytokine profiles across trajectories of self-perceived cognitive impairment among early-stage breast cancer survivors.

The aim of the current study is to identify distinct cytokine profiles in relation to self-perceived cognitive trajectories. In our study cohort (n = 128), early-stage breast cancer patients were categorized into no impairment reported, acute, delayed, persistent and intermittent cognitive decline respectively. Pro-inflammatory cytokines were elevated compared to baseline; with TNF-α implicated in the acute cognitive trajectory while IL-6 and IL-8 were involved in the persistent cognitive trajectory. Our findings help to further our understanding of cytokine profiles implicated in cancer-related cognitive impairment (CRCI) and support the use of cytokine levels as biomarkers of cognitive decline over time

Understanding Contextual Differences in Residential LTC Provision for Cross-National Research : Identifying Internationally Relevant CDEs

Long-term care (LTC) reflects a growing emphasis on person-centered care (PCC), with services oriented around individuals' needs and preferences. Addressing contextual and cultural differences across countries offers important insight into factors that facilitate or hinder application of PCC practices within and across countries. This article takes an international lens to consider country-specific contexts of LTC, describing preliminary steps to develop common data elements that capture contextual differences across LTC settings globally. Through an iterative series of online, telephone, and in-person sessions, we engaged in in-depth discussions with 11 colleague experts in residential LTC and coauthors from six countries (China and Hong Kong, England, Sweden, Thailand, Trinidad and Tobago, and the United States). Our discussions yielded rich narrative describing a vast range in types of LTC settings, leading to our development of a working definition of residential LTC. Scope of services, funding, ownership, and regulations varied greatly across countries and across different residential LTC settings within countries. Moving forward, we recommend expanding our activities to countries that reflect different stages of residential LTC development. Our goal is to contribute to a larger initiative underway by the WE-THRIVE consortium to establish a global research measurement infrastructure that advances PCC internationally.Peer reviewe

Embrittlement of MISSE 5 Polymers After 13 Months of Space Exposure

Understanding space environment induced degradation of spacecraft materials is essential when designing durable and stable spacecraft components. As a result of space radiation, debris impacts, atomic oxygen interaction, and thermal cycling, the outer surfaces of space materials degrade when exposed to low Earth orbit (LEO). The objective of this study was to measure the embrittlement of 37 thin film polymers after LEO space exposure. The polymers were flown aboard the International Space Station and exposed to the LEO space environment as part of the Materials International Space Station Experiment 5 (MISSE 5). The samples were flown in a nadir-facing position for 13 months and were exposed to thermal cycling along with low doses of atomic oxygen, direct solar radiation and omnidirectional charged particle radiation. The samples were analyzed for space-induced embrittlement using a bend-test procedure in which the strain necessary to induce surface cracking was determined. Bend-testing was conducted using successively smaller mandrels to apply a surface strain to samples placed on a semi-suspended pliable platform. A pristine sample was also tested for each flight sample. Eighteen of the 37 flight samples experienced some degree of surface cracking during bend-testing, while none of the pristine samples experienced any degree of cracking. The results indicate that 49 percent of the MISSE 5 thin film polymers became embrittled in the space environment even though they were exposed to low doses (approx.2.75 krad (Si) dose through 127 mm Kapton) of ionizing radiation

The Function of Steroid Receptor Coactivator-1 in Normal Tissues and Cancer

In 1995, the steroid receptor coactivator-1 (SRC-1) was identified as the first authentic steroid receptor coactivator. Since then, the SRC proteins have remained at the epicenter of coregulator biology, molecular endocrinology and endocrine-related cancer. Cumulative works on SRC-1 have shown that it is primarily a nuclear receptor coregulator and functions to construct highly specific enzymatic protein complexes which can execute efficient and successful transcriptional activation of designated target genes. The versatile nature of SRC-1 enables it to respond to steroid dependent and steroid independent stimulation, allowing it to bind across many families of transcription factors to orchestrate and regulate complex physiological reactions. This review highlights the multiple functions of SRC-1 in the development and maintenance of normal tissue functions as well as its major role in mediating hormone receptor responsiveness. Insights from genetically manipulated mouse models and clinical data suggest SRC-1 is significantly overexpressed in many cancers, in particular, cancers of the reproductive tissues. SRC-1 has been associated with cellular proliferation and tumor growth but its major tumorigenic contributions are promotion and execution of breast cancer metastasis and mediation of resistance to endocrine therapies. The ability of SRC-1 to coordinate multiple signaling pathways makes it an important player in tumor cells' escape of targeted therapy

How usable are digital collections for endangered languages? A review

Here, we report on pilot research on the extent to which language collections in digital linguistic archives are discoverable, accessible, and usable for linguistic research. Using a test case of common tasks in phonetic and phonological documentation, we evaluate a small random sample of collections and find substantial, striking problems in all domains. Of the original 20 collections, only six had digitized audio files with associated transcripts (preferably phrase-aligned). That is, only 30% of the collections in our sample were even potentially suitable for any type of phonetic work (regardless of quality of recording). Information about the contents of the collection was usually discoverable, though there was variation in the types of information that could be easily searched for in the collection. Though eventually three collections were aligned, only one collection was successfully force-aligned from the archival materials without substantial intervention. We close with recommendations for archive depositors to facilitate discoverability, accessibility, and functionality of language collections. Consistency and accuracy in file naming practices, data descriptions, and transcription practices is imperative. Providing a collection guide also helps. Including useful search terms about collection contents makes the materials more findable. Researchers need to be aware of the changes to collection structure that may result from archival uploads. Depositors need to consider how their metadata is included in collections and how items in the collection may be matched to each other and to metadata categories. Finally, if our random sample is indicative, linguistic documentation practices for future phonetic work need to change rapidly, if such work from archival collections is to be done in future

A Review of the Impact of Occupational Contact Dermatitis on Quality of Life

Occupational contact dermatitis (OCD) is the most common occupational skin disease in many countries. We reviewed the current evidence on how OCD impacts on quality of life (QoL). The three commonly used QoL questionnaires in OCD were the Short-Form Health Survey (SF-36), the Dermatology Life Quality Index (DLQI), and the Skindex. Despite the availability of a variety of validated QoL instruments, none of them is specific to OCD or entirely adequate in capturing the impact of OCD on QoL. Nonetheless, the results of this paper do suggest a significant impact. Use of QoL measures in clinical settings will provide patients with an opportunity to express their concerns and assist clinicians to evaluate the effectiveness of management beyond the clinical outcomes. This paper also highlights the lack of a disease-specific QOL instrument and the importance of developing a validated measure to assess QOL in OCD, enabling comparison across countries and occupational groups